European Journal of Dentistry 杂志-刊鹿论文编译

Potential of Distilled Liquid Smoke Derived from Coconut ( Cocos nucifera L) Shell for Traumatic Ulcer Healing in Diabetic Rats

Abstract:

Objective Distilled liquid smoke (DLS) is a result of coconut processing by-product that not only serves as a natural food preservative but also has a promising therapeutic effect. The healing potential of DLS derived from coconut ( Cocos nucifera L) shell was investigated on a traumatic ulcer with the diabetic rat. Materials and Methods DLS was analyzed the component by gas chromatograph mass spectrometry. Diabetic condition was induced by alloxan in 55 male Wistar rats. Ten mm of traumatic ulcer was made along the labial fornix incisive inferior after the diabetic condition was confirmed. Then DLS coconut shell, benzydamine hydrochloride, and sterile distilled water were applied topically for 3, 5, and 7 days. The potential healing was evaluated based on the expression of nuclear factor kappa beta (NFκB) and tumor necrosis factor alpha (TNF-α) on macrophages using immunohistochemical staining and the amount of collagen using Masson Trichome staining. The difference between each group was analyzed using one-way analysis of variance. The least significant difference test is used to determine the significant difference ( p < 0.05). Results The major compounds found were phenol (36.6%), 2-methoxyphenol (guaiacol) (25.2%), furfural (17.8%), and 4-ethyl-2-methoxyphenol (3.5%) with 28 other minor constituents. The lowest NFκB and TNF-α expression on macrophage was observed by topical application of DLS derived from coconut shell for 3, 5, and 7 days of treatment. The amount of collagen was increased and indicated by the highest result of DLS compared to others. Conclusion The DLS derived from coconut ( Cocos nucifera L) shell was able to improve traumatic ulcer healing in a person with diabetes.

Author Listing： Meircurius Dwi Condro Surboyo;Ira Arundina;Retno Pudji Rahayu;Dieni Mansur;Taufan Bramantoro

Volume： 13

Pages： 271 - 279

DOI： 10.1055/s-0039-1693527

Language： English

Journal： European Journal of Dentistry

European Journal of Dentistry

影响因子：0.0

是否综述期刊：否

是否OA：否

是否预警：不在预警名单内

发行时间：-

ISSN：1305-7456

发刊频率：-

收录数据库：Scopus收录

出版国家/地区：-

出版社：Thieme

期刊介绍

年发文量	209
国人发稿量	-
国人发文占比	0%
自引率	0.0%
平均录取率	-
平均审稿周期	-
版面费	-
偏重研究方向	Dentistry-Dentistry (all)
期刊官网	-
投稿链接	-

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预警情况

时间	预警情况
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q0区

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WOS期刊SCI分区（2021-2022年最新版）

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版本	大类学科	小类学科	Top期刊	综述期刊
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