Forensic Toxicology 怎么样-刊鹿论文编译

Development and validation of a GC–MS/MS method for the determination of 11 amphetamines and 34 synthetic cathinones in whole blood

Abstract:

PurposePsychoactive compounds that contain a phenylethylamine structure (such as amphetamine-type stimulants and synthetic cathinones) are one of the major classes of stimulants on the recreational drug market. Approximately 670 new psychoactive substances (NPS) are monitored only in Europe; however, new psychoactive compounds are being developed for illicit trade each year. In this context, the development of new analytical procedures for the determination of such compounds in biological specimens for forensic toxicology is of great importance.MethodsGas chromatography–tandem mass spectrometry (GC–MS/MS) technique was applied for analysis of amphetamines and synthetic cathinones. The volumes of 200 µL of each whole blood sample and 1\xa0mL of liquid-liquid extraction solvent were used for extraction, followed by pentafluoropropionyl derivatization.ResultsA high-throughput, robust, rapid, and sensitive procedure involving a simple liquid-liquid extraction for the simultaneous determination of 45 amphetamine-type stimulants and synthetic cathinones in whole blood was developed. The assay was validated based on its recovery (83.2–106%), interday accuracy (89.0–108%), and interday precision (≤\u20098.1%). In view of the low limits of detection (ranged between 0.02 and 0.72\xa0ng/mL) and limits of quantification (1 and 2.5\xa0ng/mL), the developed method can serve as a less expensive and more ecologically friendly alternative to the liquid chromatography–tandem mass spectrometric methods.ConclusionsTo the best of our knowledge, this is the first work presenting a GC–MS/MS method for the determination of NPS in blood samples. The presented procedure was applied to authentic samples from forensic cases, demonstrating its utility in the quantification of a wide number of psychoactive substances in routine toxicological analyses. The developed procedure can also be easily expanded to additional compounds.

Author Listing： Mateusz Kacper Woźniak;Laura Banaszkiewicz;Marek Wiergowski;Ewa Tomczak;Marzena Kata;Beata Szpiech;Jacek Namieśnik;Marek Biziuk

Volume： 38

Pages： 42-58

DOI： 10.1007/s11419-019-00485-y

Language： English

Journal： Forensic Toxicology

Forensic Toxicology

FORENSIC TOXICOL

影响因子：3.0

是否综述期刊：否

是否OA：否

是否预警：不在预警名单内

发行时间：2006

ISSN：1860-8965

发刊频率：Semiannual

收录数据库：SCIE/Scopus收录

出版国家/地区：JAPAN

出版社：Springer Singapore

期刊介绍

The journal Forensic Toxicology provides an international forum for publication of studies on toxic substances, drugs of abuse, doping agents, chemical warfare agents, and their metabolisms and analyses, which are related to laws and ethics. It includes original articles, reviews, mini-reviews, short communications, and case reports. Although a major focus of the journal is on the development or improvement of analytical methods for the above-mentioned chemicals in human matrices, appropriate studies with animal experiments are also published.Forensic Toxicology is the official publication of the Japanese Association of Forensic Toxicology (JAFT) and is the continuation of the Japanese Journal of Forensic Toxicology (ISSN 0915-9606).

《法医毒理学》杂志提供了一个国际论坛，供发表关于有毒物质、滥用药物、兴奋剂、化学战剂及其代谢和分析的研究，这些研究与法律和伦理有关。它包括原创文章、综述、小型综述、简短通信和病例报告。虽然该杂志的主要重点是开发或改进人体基质中上述化学品的分析方法，但也发表了有关动物实验的研究。《法医毒理学》是日本法医毒理学协会（ JAFT ）的官方出版物，是《日本法医毒理学杂志》（ ISSN 0915 - 9606 ）的延续。

年发文量	31
国人发稿量	2
国人发文占比	5%
自引率	3.3%
平均录取率	-
平均审稿周期	>12周，或约稿
版面费	US$4190
偏重研究方向	TOXICOLOGY-
期刊官网	https://www.springer.com/11419/?utm_medium=display&utm_source=letpub&utm_content=text_link&utm_term=null&utm_campaign=MLSR_11419_AWA1_CN_CNPL_letpb_mp
投稿链接	https://www.editorialmanager.com/foto/

质量指标占比

研究类文章占比	OA被引用占比	撤稿占比	出版后修正文章占比
93.55%	41.18%	0.00%	1.61%

预警情况

时间	预警情况
2025年03月发布的2025版	不在预警名单中
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q2区

版本	按学科	分区
WOS期刊SCI分区（2021-2022年最新版）
	TOXICOLOGY	Q3

中科院分区

版本	大类学科	小类学科	Top期刊	综述期刊
	医学 4区	TOXICOLOGY 毒理学 4区	否	否
2021年12月基础版	医学 3区	TOXICOLOGY 毒理学 3区	否	否
2021年12月升级版	医学 3区	TOXICOLOGY 毒理学 3区	否	否
2020年12月旧的升级版	医学 3区	TOXICOLOGY 毒理学 3区	否	否
2022年12月最新升级版	医学 4区	TOXICOLOGY 毒理学 4区	否	否