BMJ Open Respiratory Research 投稿经验-刊鹿论文编译

Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

Abstract:

Introduction To understand the puberty-related sex shift in the prevalence of asthma and rhinitis as single entities and as respiratory multimorbidities, we investigated if there is also a sex-specific and puberty-related pattern of their incidences. Methods We used harmonised questionnaire data from 18\u2009451 participants in five prospective observational European birth cohorts within the collaborative MeDALL (Mechanisms of the Development of Allergy) project. Outcome definitions for IgE-associated and non-IgE-associated asthma, rhinitis and respiratory multimorbidity (first occurrence of coexisting asthma and rhinitis) were based on questionnaires and the presence of specific antibodies (IgE) against common allergens in serum. For each outcome, we used proportional hazard models with sex–puberty interaction terms and conducted a one-stage individual participant data meta-analysis. Results Girls had a lower risk of incident asthma (adjusted HR 0.67, 95%\u2009CI 0.61 to 0.74), rhinitis (0.73, 0.69 to 0.78) and respiratory multimorbidity (0.58, 0.51 to 0.66) before puberty compared with boys. After puberty onset, these incidences became more balanced across the sexes (asthma 0.84, 0.64 to 1.10; rhinitis 0.90, 0.80 to 1.02; respiratory multimorbidity 0.84, 0.63 to 1.13). The incidence sex shift was slightly more distinct for non-IgE-associated respiratory diseases (asthma 0.74, 0.63 to 0.87 before vs 1.23, 0.75 to 2.00 after puberty onset; rhinitis 0.88, 0.79 to 0.98 vs 1.20, 0.98 to 1.47; respiratory multimorbidity 0.66, 0.49 to 0.88 vs 0.96, 0.54 to 1.71) than for IgE-associated respiratory diseases. Discussion We found an incidence ‘sex shift’ in chronic respiratory diseases from a male predominance before puberty to a more sex-balanced incidence after puberty onset, which may partly explain the previously reported sex shift in prevalence. These differences need to be considered in public health to enable effective diagnoses and timely treatment in adolescent girls.

Author Listing： Cynthia Hohmann;Theresa Keller;Ulrike Gehring;Alet Wijga;Marie Standl;Inger Kull;Anna Bergstrom;Irina Lehmann;Andrea von Berg;Joachim Heinrich;Susanne Lau;Ulrich Wahn;Dieter Maier;Josep Anto;Jean Bousquet;Henriette Smit;Thomas Keil;Stephanie Roll

Volume： 6

Pages： None

DOI： 10.1136/bmjresp-2019-000460

Language： English

Journal： BMJ Open Respiratory Research

BMJ Open Respiratory Research

BMJ OPEN RESPIR RES

影响因子：3.4

是否综述期刊：否

是否OA：是

是否预警：不在预警名单内

发行时间：-

ISSN：2052-4439

发刊频率：-

收录数据库：SCIE/Scopus收录/DOAJ开放期刊

出版国家/地区：United Kingdom

出版社：BMJ Publishing Group

期刊介绍

年发文量	173
国人发稿量	38
国人发文占比	22.07%
自引率	0.0%
平均录取率	-
平均审稿周期	12 Weeks
版面费	-
偏重研究方向	RESPIRATORY SYSTEM-
期刊官网	http://bmjopenrespres.bmj.com/
投稿链接	-

质量指标占比

研究类文章占比	OA被引用占比	撤稿占比	出版后修正文章占比
97.11%	98.59%	-	-

预警情况

时间	预警情况
2025年03月发布的2025版	不在预警名单中
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q2区

版本	按学科	分区
WOS期刊SCI分区（2021-2022年最新版）
	RESPIRATORY SYSTEM	Q2

中科院分区

版本	大类学科	小类学科	Top期刊	综述期刊
	医学 3区	RESPIRATORY SYSTEM 呼吸系统 3区	否	否
2022年12月最新升级版	医学 3区	RESPIRATORY SYSTEM 呼吸系统 3区	否	否