International Journal of Nephrology 审稿状态变化-刊鹿论文编译

The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis

Abstract:

Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer. Cathepsin B is a lysosomal cysteine protease that degrades ECM, but its role in the PF remains unclear. Thus, we investigated the role of cathepsin B in PF. Procathepsin B was measured in the 73 PD effluents of 68 patients. Procathepsin B and cathepsin B after exposure of glucose and the effects of cathepsin B on the expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), and urokinase-type plasminogen activator (uPA) were measured in the supernatant of cultured human peritoneal mesothelial cells (HPMCs). The effect of cathepsin B and its inhibitor, cystatin C, on PF was investigated in the murine model. Procathepsin B was measured at 3.6\u2009μg/L in serum and 5.4\u2009μg/L in PD effluent and positively correlated to the cancer antigen (CA) 125. The treatment with 4.25% glucose increased procathepsin B by 3.1-fold and cathepsin B by 5.9-fold in the HPMCs. Cathepsin B induced the secretion of MMP-1, -2, and -3 and TIMP-1 in the HPMCs, but uPA was not excreted. In the PF murine models, cathepsin B reduced the thickness of the submesothelial layer and cystatin C attenuated the effect of cathepsin B. HPMCs secrete cathepsin B with exposure of PD solution, and cathepsin B might help protect against PF.

Author Listing： Su Ah Sung;Dong Hee Kim;Kook-Hwan Oh;Sang Youb Han;Kum Hyun Han

Volume： 2019

Pages： None

DOI： 10.1155/2019/4150656

Language： English

Journal： International Journal of Nephrology

International Journal of Nephrology

INT J NEPHROL

影响因子：1.4

是否综述期刊：否

是否OA：是

是否预警：不在预警名单内

发行时间：-

ISSN：2090-214X

发刊频率：-

收录数据库：ESCI/Scopus收录/DOAJ开放期刊

出版国家/地区：United Kingdom

出版社：Hindawi Limited

期刊介绍

年发文量	14
国人发稿量	1
国人发文占比	5.26%
自引率	0.0%
平均录取率	-
平均审稿周期	17 Weeks
版面费	-
偏重研究方向	UROLOGY & NEPHROLOGY-
期刊官网	https://www.hindawi.com/journals/ijn
投稿链接	-

质量指标占比

研究类文章占比	OA被引用占比	撤稿占比	出版后修正文章占比
85.71%	100.00%	-	-

预警情况

时间	预警情况
2025年03月发布的2025版	不在预警名单中
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q3区

版本	按学科	分区
WOS期刊SCI分区（2021-2022年最新版）
	UROLOGY & NEPHROLOGY	Q3

中科院分区

版本	大类学科	小类学科	Top期刊	综述期刊
暂无数据