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Skeletal Muscle Regenerative Engineering

Abstract:
Skeletal muscles have the intrinsic ability to regenerate after minor injury, but under certain circumstances such as severe trauma from accidents, chronic diseases, or battlefield injuries the regeneration process is limited. Skeletal muscle regenerative engineering has emerged as a promising approach to address this clinical issue. The regenerative engineering approach involves the convergence of advanced materials science, stem cell science, physical forces, insights from developmental biology, and clinical translation. This article reviews recent studies showing the potential of the convergences of technologies involving biomaterials, stem cells, and bioactive factors in concert with clinical translation, in promoting skeletal muscle regeneration. Several types of biomaterials such as electrospun nanofibers, hydrogels, patterned scaffolds, decellularized tissues, and conductive matrices are being investigated. Detailed discussions are given on how these biomaterials can interact with cells and modulate their behavior through physical, chemical, and mechanical cues. In addition, the application of physical forces such as mechanical and electrical stimulation is reviewed as strategies that can further enhance muscle contractility and functionality. The review also discusses established animal models to evaluate regeneration in two clinically relevant muscle injuries: volumetric muscle loss (VML) and muscle atrophy upon rotator cuff injury. Regenerative engineering approaches using advanced biomaterials, cells, and physical forces, developmental cues along with insights from immunology, genetics, and other aspects of clinical translation hold significant potential to develop promising strategies to support skeletal muscle regeneration.Lay SummarySkeletal muscle has robust regeneration properties, but in extreme conditions, the regeneration ability is hindered. It remains a common clinical problem that could lead to long-term disability. The available treatments such as muscle flap transposition present various limitations. To address these limitations, promising strategies based on regenerative engineering are being developed. This review article discusses the different approaches to tissue regeneration using the regenerative engineering paradigm. A specific discussion involves biomaterials and their interactions with cells and bioactive molecules. In addition, the advantages of physical and mechanical stimulation in muscle regeneration are discussed.
Author Listing: Xiaoyan Tang;Leila Daneshmandi;Guleid Awale;Lakshmi S. Nair;Cato T. Laurencin
Volume: None
Pages: 1-19
DOI: 10.1007/s40883-019-00102-9
Language: English
Journal: Regenerative Engineering and Translational Medicine

Regenerative Engineering and Translational Medicine

REGEN ENG TRANSL MED

影响因子:1.9
是否综述期刊:否
是否OA:否
是否预警:不在预警名单内
发行时间:-
ISSN:2364-4133
发刊频率:4 issues per year
收录数据库:ESCI/Scopus收录
出版国家/地区:-
出版社:Springer Nature

期刊介绍

Regenerative Engineering is an international journal covering convergence of the disciplines of tissue engineering, advanced materials science, stem cell research, the physical sciences, and areas of developmental biology. This convergence brings exciting opportunities to translate bench-top research into bedside methods, allowing the possibility of moving beyond maintaining or repairing tissues to regenerating them. The journal encourages both top-down engineering approaches and bottom-up strategies integrating materials science with stem cell research and developmental biology. Convergence papers on instructive biomaterials, stimuli-responsive biomaterials, micro- and nano-patterning for regenerative engineering, elastomeric biomaterials, hydrogels for tissue engineering, and rapid prototyping and bioprinting approaches are particularly welcome. The journal provides a premier, single-blind peer-reviewed forum for the publication of original papers, authoritative reviews, rapid communications, news and views, and opinion papers addressing the most important issues and efforts toward successfully regenerating complex human tissues and organs. All research articles feature a lay abstract highlighting the relevance and future impact for patients, government and other health officials, and members of the general public. Bridging the gap between the lab and the clinic, the journal also serves as a dedicated platform for showcasing translational research that brings basic scientific research and discoveries into clinical methods and therapies, contributing to the improvement of human health care.Topics covered in Regenerative Engineering and Translational Medicine include:Advanced materials science for regenerative and biomedical applicationsStem cells for tissue regenerationDrug delivery for tissue regenerationNanomaterials and nanobiotechnology for tissue regenerationStudies combining tissue engineering/regeneration with developmental biologyConvergence research in pre-clinical and clinical phases

《再生工程》是一本国际性期刊,涵盖组织工程、先进材料科学、干细胞研究、物理科学和发育生物学等学科。这种融合带来了将实验室研究转化为临床方法的令人兴奋的机会,使其有可能超越组织的维护或修复而进行再生。该杂志鼓励自上而下的工程方法和自下而上的战略,整合材料科学与干细胞研究和发育生物学。特别欢迎关于指导性生物材料、刺激响应性生物材料、再生工程的微米和纳米图案、弹性生物材料、组织工程的水凝胶以及快速原型和生物打印方法的论文。该杂志提供了一个主要的、单盲同行评审论坛,用于发表原创论文、权威评论、快速通信、新闻和观点以及意见论文,讨论最重要的问题和成功再生复杂人体组织和器官的努力。所有研究文章都有一个简明摘要,强调了对患者、政府和其他卫生官员以及普通公众的相关性和未来影响。《再生工程》和《转化医学》的主题包括:用于再生和生物医学应用的先进材料科学用于组织再生的干细胞用于组织再生的药物输送用于组织再生的纳米材料和纳米生物技术用于组织再生的纳米材料和纳米生物技术将组织工程/再生与发育生物学相结合的研究临床前和临床阶段的融合研究

年发文量 42
国人发稿量 -
国人发文占比 0%
自引率 5.3%
平均录取率 -
平均审稿周期 -
版面费 US$2890
偏重研究方向 ENGINEERING, BIOMEDICAL-
期刊官网 https://www.springer.com/40883/?utm_medium=display&utm_source=letpub&utm_content=text_link&utm_term=null&utm_campaign=MPSR_40883_AWA1_CN_CNPL_letpb_mp
投稿链接 https://www.editorialmanager.com/RETM/

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
50.00% 7.87% - -

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q3区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
ENGINEERING, BIOMEDICAL Q4

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
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