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Genetic Variation in Disease Resistance Against White Spot Syndrome Virus (WSSV) in Liptopenaeus vannamei

Abstract:
White Spot Syndrome Virus (WSSV) is the most damaging pathogen in terms of production and economic losses for the shrimp sector world-wide. Estimation of heritability for WSSV resistance was made in this study to obtain necessary parameter inputs for broadening the breeding objectives of an ongoing selective breeding programme for Whiteleg shrimp (Liptopenaeus vannamei) that has focussed exclusively on improving growth performance since 2014. The present study involved a disease challenge test experiment using a total of 15,000 shrimps from 150 full- and half-sib families (100 individuals per family). Survival rates were recorded at six different experimental periods: 1–3 days (S1), 1–5 days (S2), 1–7 days (S3), 1–9 days (S4), 1–12 days (S5), and 1–15 days (S6) and were used as measures of WSSV resistance. There was significant variation in WSSV resistance among families studied. Quantitative-real time PCR (qPCR) analysis showed that the amount of viral titer (viral load) was significantly lower in high than low resistance families. Analyses of heritability were carried out using linear mixed model (LMM) and threshold logistic generalized model (TLGM). Both linear and threshold models used showed that the heritability (h2) for WSSV resistance was moderate in the early infection phases (S1–S4), whilst a low h2 value was observed for survival after 12 and 15 days of the challenge test (S5 and S6). The transformed heritabilities for WSSV resistance ranged from 1 to 31% which were somewhat lower than those estimated on the liability scale. Genetic correlations between survival rates measured over six different days post-infection were high and positive (0.82–0.99). The phenotypic correlations ranged from 0.31 ± 0.01 to 0.97 ± 0.01. The genetic correlations between body weights and WSSV resistance were negative. Our results on the heritability and genetic correlations show that improvement of WSSV resistance can be achieved through selective breeding in this population of Whiteleg shrimp.
Author Listing： Trinh Thi Trang;Nguyen Huu Hung;Nguyen Huu Ninh;Wayne Knibb;Nguyen Hong Nguyen
Volume： 10
Pages： None
DOI： 10.3389/fgene.2019.00264
Language： English
Journal： Frontiers in Genetics

Frontiers in Genetics

FRONT GENET

影响因子：2.8
是否综述期刊：否
是否OA：是
是否预警：不在预警名单内
发行时间：-
ISSN：1664-8021
发刊频率：-
收录数据库：SCIE/Scopus收录/DOAJ开放期刊
出版国家/地区：UNITED STATES
出版社：Frontiers Media S.A.

期刊介绍

Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public.The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.

《遗传学前沿》出版了严格的同行评审研究，涉及从人类到植物到牲畜和其他模式生物的所有生命领域的基因和基因组。由世界顶尖专家组成的杰出编辑委员会领导，这本多学科、开放获取的期刊走在前沿，向研究人员、学者、临床医生、政策制定者和公众传播尖端研究。遗传研究和基因组对各种生物过程的影响都有详细的文献记录。然而，大部分的发现还在后面。一个新的时代正在看到基因组的功能和可变性、遗传和基因组工具的使用以及对各种生物现象的遗传基础的分析方面的重大发展。

年发文量 1004
国人发稿量 581
国人发文占比 57.82%
自引率 3.6%
平均录取率 -
平均审稿周期 14 Weeks
版面费 -
偏重研究方向 Biochemistry, Genetics and Molecular Biology-Molecular Medicine
期刊官网 https://www.frontiersin.org/journals/genetics
投稿链接 https://www.frontiersin.org/submission/SubmissionHome.aspx?domainId=1&fieldId=30&specialtyId=0&entityType=1&entityId=240

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88.55% 99.52% - -

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