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Early Inflammatory Status Related to Pediatric Obesity

Abstract:
Background: Obese individuals are often in a chronic inflammatory condition due to the malfunction of immune-related activities in the adipose tissue, involving a transient infiltration of neutrophils within the abdominal fat and their binding to adipocytes. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are considered cost-effective markers for the detection of subclinical inflammation. Our study intends to assess the early stages of inflammation associated with overweight and obesity in children. Materials and Methods: We performed a prospective study with 164 children, aged between 5 and 18 years, admitted to a Pediatric Tertiary Hospital in Romania between January 2018 and January 2019. The patients were divided according to body mass index (BMI) into two groups: Group 1: 77 overweight and obese children (BMI percentile ≥85), and Group 2: 87 children with a normal BMI, in order to evaluate the correlation between BMI and laboratory parameters (CBC, ESR, transaminase, total protein, albumin, and blood glucose levels), inflammatory biomarkers, NLR and PLR, and changes in abdominal ultrasound findings. Results: We found that the leukocyte, lymphocyte, erythrocyte, platelet, CRP, and transaminase levels were significantly higher in the overweight/obese group (p = 0.0379, p = 0.0002, p = 0.0003, p = 0.0006, p < 0.0001, p = 0.0332, and p < 0.0001, respectively). No significant statistical differences between the two groups in terms of neutrophil, hemoglobin, albumin, total protein, and glycemia levels were noted (p > 0.05). Moreover, NLR and PLR did not differ significantly between the two groups (p = 0.4674 and p = 0.9973, respectively). Conclusions: Obesity is associated with systemic low-grade inflammation which is reaching alarming rates worldwide among both children and adults. Our study proved that leukocyte, lymphocyte, erythrocyte, and platelet levels are significantly higher in overweight/obese children, emphasizing the inflammatory status related to this condition. Therefore, obesity-related studies involving pediatric patients are of major interest in order to develop appropriate methods to prevent the development of further complications in adulthood.
Author Listing: Cristina Oana Mărginean;Lorena Elena Meliţ;Dana Valentina Ghiga;Maria Oana Mărginean
Volume: 7
Pages: None
DOI: 10.3389/fped.2019.00241
Language: English
Journal: Frontiers in Pediatrics

Frontiers in Pediatrics

FRONT PEDIATR

影响因子:2.0
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:2296-2360
发刊频率:-
收录数据库:SCIE/Scopus收录/DOAJ开放期刊
出版国家/地区:SWITZERLAND
出版社:Frontiers Media S.A.

期刊介绍

Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children's Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.

儿科前沿 (影响因子2.33) 在整个领域广泛发布严格的同行评审研究,从基础研究到临床研究,应对儿科患者护理和儿童健康方面的持续挑战。莱顿大学的现场主编Arjan Te Pas和匹兹堡儿童医院的Michael L. Moritz得到了杰出的国际专家编辑委员会的支持。这本多学科开放获取期刊是在向世界各地的研究人员,学者,临床医生和公众传播和交流科学知识和有影响力的发现的最前沿。儿科前沿也以研究主题为特色,由客座副编辑管理的专题,解决儿科的重要领域。以这种方式,Frontiers可以作为发布基础和临床研究中儿科最广泛方面的渠道,包括与儿科各个方面相关的高质量评论,病例报告,社论和评论。

年发文量 1108
国人发稿量 439
国人发文占比 39.61%
自引率 0.0%
平均录取率 -
平均审稿周期 14 Weeks
版面费 US$2950
偏重研究方向 Medicine-Pediatrics, Perinatology and Child Health
期刊官网 https://www.frontiersin.org/journals/pediatrics
投稿链接 https://www.frontiersin.org/people/login?returnUrl=https%3a%2f%2fwww.frontiersin.org%2fsubmission%2fSubmissionHome.aspx%3fdomainId%3d2%26fieldId%3d61%26specialtyId%3d0%26entityType%3d1%26entityId%3d606

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
86.82% 99.59% 0.00% 1.18%

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q2区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
PEDIATRICS Q2

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
医学
3区
PEDIATRICS
儿科
3区
2021年12月
基础版
医学
3区
PEDIATRICS
儿科
2区
2021年12月
升级版
医学
3区
PEDIATRICS
儿科
3区
2020年12月
旧的升级版
医学
3区
PEDIATRICS
儿科
3区
2022年12月
最新升级版
医学
3区
PEDIATRICS
儿科
3区