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3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

Abstract:
Abstract Additive manufacturing (AM) has shown promise in designing 3D scaffold for regenerative medicine. However, many synthetic biomaterials used for AM are bioinert. Here, we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate) (PEOT)/poly(butylene terephthalate) (PBT) (PEOT/PBT) copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue engineering. PEOT/PBT have been shown to support calcification and bone bonding ability in vivo, while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in absence of osteoinductive agents. The effect of nanosilicates addition to PEOT/PBT on structural, mechanical and biological properties is investigated. Specifically, the addition of nanosilicate to PEOT/PBT improves the stability of nanocomposites in physiological conditions, as nanosilicate suppressed the degradation rate of copolymer. However, no significant increase in the mechanical stiffness of scaffold due to the addition of nanosilicates is observed. The addition of nanosilicates to PEOT/PBT improves the bioactive properties of AM nanocomposites as demonstrated in vitro. hMSCs readily proliferated on the scaffolds containing nanosilicates and resulted in significant upregulation of osteo-related proteins and production of mineralized matrix. The synergistic ability of nanosilicates and PEOT/PBT can be utilized for designing bioactive scaffolds for bone tissue engineering.
Author Listing: James K Carrow;Andrea Di Luca;Alireza Dolatshahi-Pirouz;Lorenzo Moroni;Akhilesh K Gaharwar
Volume: 6
Pages: 29 - 37
DOI: 10.1093/rb/rby024
Language: English
Journal: Regenerative Biomaterials

Regenerative Biomaterials

REGEN BIOMATER

影响因子:8.1
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:2056-3418
发刊频率:-
收录数据库:SCIE/Scopus收录/DOAJ开放期刊
出版国家/地区:United Kingdom
出版社:Oxford University Press

期刊介绍

Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.

《再生生物材料》是一本国际性、跨学科、同行评审期刊,发表生物材料和再生医学的最新进展。该杂志为发表原创研究论文、综述、临床病例报告和评论提供了一个论坛,主题与先进再生生物材料的开发有关,涉及新型再生技术和治疗方法,用于受损组织和器官的再生和修复。生物材料与细胞和组织的相互作用,特别是与干细胞的相互作用,将是特别关注的。

年发文量 150
国人发稿量 124
国人发文占比 82.76%
自引率 19.8%
平均录取率 -
平均审稿周期 10 Weeks
版面费 -
偏重研究方向 Materials Science-Biomaterials
期刊官网 https://academic.oup.com/rb
投稿链接 https://mc.manuscriptcentral.com/rb

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
87.33% 99.72% 0.00% 5.77%

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q1区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
MATERIALS SCIENCE, BIOMATERIALS Q2

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
工程技术
1区
MATERIALS SCIENCE, BIOMATERIALS
材料科学:生物材料
2区
2021年12月
基础版
工程技术
2区
MATERIALS SCIENCE, BIOMATERIALS
材料科学:生物材料
2区
2021年12月
升级版
工程技术
2区
MATERIALS SCIENCE, BIOMATERIALS
材料科学:生物材料
2区
2020年12月
旧的升级版
工程技术
2区
MATERIALS SCIENCE, BIOMATERIALS
材料科学:生物材料
2区
2022年12月
最新升级版
医学
1区
MATERIALS SCIENCE, BIOMATERIALS
材料科学:生物材料
2区