Egyptian Rheumatologist 审稿状态变化-刊鹿论文编译

Toll-like receptor (TLR9) -1486 T/C (rs187084) gene polymorphism in Egyptian patients with rheumatoid arthritis

Abstract:

Abstract Aim of the work The aim of the study was to assess the role of Toll-like receptor-9 (TLR9) gene polymorphism in rheumatoid arthritis (RA) and to evaluate its association with disease activity and severity in Egyptian patients. Patients and methods The study included 100 RA patients and 100 matched controls. Genotyping of TLR9 -1486 T/C (rs187084) gene polymorphism for all participants was performed. Medical Records-Based Index of Severity (RARBIS), modified Health Assessment Questionnaire (mHAQ), disease activity score (DAS28) and clinical and laboratory parameters of disease activity were assesses in RA patients. Anti-cyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) were also determined. Results The patients mean age was 43.7\u202f±\u202f8.9\u202fyears and were 73 females and 27 males with mean disease duration of 13.3\u202f±\u202f6.2\u202fyears. The mean DAS28 was 3.5\u202f±\u202f1.1, RARBIS was 6.6\u202f±\u202f2.8 and the mHAQ 1.4\u202f±\u202f0.8. The frequency of the TLR9 TT genotype carriers were significantly higher in RA patients than in controls (27% and 9% respectively). Similarly, the T allele was significantly more frequent in RA patients in comparison to the controls (56.5% and 42% respectively). No significant association was found between the TLR9 genotypes with the gender or the age at disease onset. The clinical and laboratory parameters reflecting disease activity showed no association with the TLR9 genotype. No significant association was found between the TRL9 genotyping with the RARBIS or presence of RF or anti-CCP antibodies. Conclusion TLR9 gene polymorphism -1486 T/C is associated with the increased RA susceptibility in Egyptian patients.

Author Listing： Marwa K. Hegazy;Fatma A. Auf;Nanis O. Neseem;Mohammad F. Al-Harrass

Volume： 41

Pages： 173-176

DOI： 10.1016/J.EJR.2018.10.001

Language： English

Journal： The Egyptian Rheumatologist

Egyptian Rheumatologist

EGYPT RHEUMATOL

影响因子：1.0

是否综述期刊：否

是否OA：是

是否预警：不在预警名单内

发行时间：-

ISSN：1110-1164

发刊频率：-

收录数据库：ESCI/Scopus收录/DOAJ开放期刊

出版国家/地区：Egypt

出版社：Elsevier

期刊介绍

年发文量	46
国人发稿量	-
国人发文占比	0%
自引率	30.0%
平均录取率	-
平均审稿周期	39 Weeks
版面费	US$0
偏重研究方向	RHEUMATOLOGY-
期刊官网	http://www.journals.elsevier.com/the-egyptian-rheumatologist/
投稿链接	-

质量指标占比

研究类文章占比	OA被引用占比	撤稿占比	出版后修正文章占比
97.83%	63.89%	-	-

预警情况

时间	预警情况
2025年03月发布的2025版	不在预警名单中
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q4区

版本	按学科	分区
WOS期刊SCI分区（2021-2022年最新版）
	RHEUMATOLOGY	Q4

中科院分区

版本	大类学科	小类学科	Top期刊	综述期刊
暂无数据