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The effect of Malaysian stingless bee, Trigona spp. honey in promoting proliferation of the undifferentiated stem cell

Abstract:
Stem cells provide various potential applications in regenerative medicine through its ability of \nself-renewal and differentiation. Among the various stem cells, dental pulp stem cells (DPSCs) have shown \nencouraging results in their ability to regenerate. Honey has been used in traditional culture as a natural \nmedicine in supporting wound healing. Yet, very few studies on honey were conducted for its potential as \na proliferative agent for stem cells. The aim of this study is to evaluate the stability of two Trigona spp. \nhoneys (1 and 2) added in culture media and its proliferative effect on DPSCs. Both honeys were diluted \nwith standard culture medium through dilution process to prepare the concentrations of 0.01%, 0.04%, \n0.10% and 0.25%. DPSCs were treated with the diluted honeys for 24 hours. The proliferative activity was \ndetermined through the images taken using an inverted microscope for every six hours. In addition, the \nMTT assay was conducted to determine the cell viability of DPSCs when treated with both honey 1 and 2 \nat various concentrations. The results showed a stable culture media added with honey for three days and \na dose-dependent proliferative effect of both Trigona spp. honey samples on DPSCs. Optimum \nproliferative effects were observed at 24 hours for both Trigona spp. honey 1 and 2 on DPSCs. The \noptimum concentration of Trigona spp. honey 1 was from 0.04% to 0.10% and Trigona spp. honey 2 was \nbelow 0.01%. It is concluded that Trigona spp. honey has a promising proliferative effect on DPSCs.
Author Listing: Mohd Amin Marwan Mohamad;Muhammad Alif Mazlan;Muhammad Ibrahim;Afzan Mat Yusof;Shamsul Azlin Ahmad Shamsuddin;Nik Fakhuruddin Nik Hassan;Hussin Muhammad;Muhammad Lokman Isa
Volume: None
Pages: 10-19
DOI: 10.35118/APJMBB.2019.027.1.02
Language: English
Journal: Asia-pacific Journal of Molecular Biology and Biotechnology

Asia-Pacific Journal of Molecular Biology and Biotechnology

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ISSN:0128-7451
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收录数据库:Scopus收录
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出版社:Universiti Putra Malaysia

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偏重研究方向 Biochemistry, Genetics and Molecular Biology-Biotechnology
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