Critical Reviews in Biomedical Engineering 是几区的-刊鹿论文编译

Multi-Biomarker Detection Following Traumatic Brain Injury.

Abstract:

The Centers for Disease Control and Prevention estimates almost two million traumatic brain injuries (TBIs) occur annually in the U.S., resulting in nearly $80 billion of economic burden. Despite its prevalence, current TBI diagnosis methods mainly rely on cognitive assessments vulnerable to subjective interpretation, thus highlighting the critical need to develop effective unbiased diagnostic methods. The presented study aims to assess the feasibility of a rapid multianalyte TBI blood diagnostic. Specifically, two electrochemical impedance techniques were used to evaluate four biomarkers: glial fibrillary acidic protein, neuron specific enolase (NSE), S-100β, and tumor necrosis factor-α. First, these biomarkers were characterized in purified solutions (detection limit, DL = 2-5 pg/mL), then verified in spiked whole blood and plasma solutions (90% whole blood DL = 14-67 pg/mL). Finally, detection of two of these biomarkers was validated in a controlled cortical impact model of TBI in rats, where a statistical difference between NSE and S-100β concentrations differed several days postinjury (p = 0.02 and p = 0.06, respectively). A statistical difference between mild and moderate injury was found at the various time points. The proposed diagnostic method enabled preliminary quantification of TBI-relevant biomarkers in complex media without the use of expensive electrode coatings or membranes. Collectively, these data demonstrate the feasibility of using electrochemical impedance techniques to rapidly detect TBI biomarkers and lay the groundwork for development of a novel method for quantitative diagnostics of TBI.

Author Listing： Brittney A Cardinell;Caroline P Addington;Sarah E Stabenfeldt;Jeffrey T La Belle

Volume： 47 3

Pages： \n 193-206\n

DOI： 10.1615/CRITREVBIOMEDENG.2019026108

Language： English

Journal： Critical reviews in biomedical engineering

Critical Reviews in Biomedical Engineering

影响因子：0.0

是否综述期刊：否

是否OA：否

是否预警：不在预警名单内

发行时间：-

ISSN：0278-940X

发刊频率：-

收录数据库：Scopus收录

出版国家/地区：-

出版社：Begell House

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自引率	0.0%
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偏重研究方向	Engineering-Biomedical Engineering
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时间	预警情况
2025年03月发布的2025版	不在预警名单中
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2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q0区

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WOS期刊SCI分区（2021-2022年最新版）

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