Egyptian Journal of Medical Human Genetics 影响因子-刊鹿论文编译

The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Abstract:

Since first reported having the association with essential hypertension, angiotensin II type 1 receptor (AT1R) A1166C was globally investigated worldwide. However, controversy was found. Furthermore, previous meta-analyses did not adequate to clarify the precise correlation due to some limitations. Therefore, we aimed to perform a meta-analysis concerning the association between AT1R A1166C single-nucleotide polymorphism (SNP) and the risk of essential hypertension with eliminating the limitations of previous studies. A meta-analysis was conducted from February to March 2019. Some information related to sample size of hypertension and control groups and genotype frequencies of hypertension and control groups were extracted from each study. Data were analyzed using fixed or random effect model to determine the overall correlation. A total of 45 papers consisting of 11911 cases and 1340 controls were enrolled for the study. Our overall analysis showed that C allele and AC genotype of AT1R A1166C was associated with 1.18-fold and 1.15-fold respectively increased risk of essential hypertension, while the decreased risk of essential hypertension was observed in A allele and AA genotype. In sub-group analysis, increased risk of essential hypertension was found in C allele, AC genotype, and CC genotype of both Asian population and PCR-RFLP sub-groups, while decreased risk was observed in A allele and AA genotype. Our meta-analysis reveals that AT1R A1166C remains a valuable SNP having an association with the risk of essential hypertension.

Author Listing： Jonny Karunia Fajar;Melly Susanti;Budi Susetio Pikir;Putu Nina Berlinda Saka;Erdo Puncak Sidarta;Fredo Tamara;Rizal Rahmanda Akbar;Saga Aditya Hutama;Atma Gunawan;Teuku Heriansyah

Volume： 20

Pages： None

DOI： 10.1186/s43042-019-0016-3

Language： English

Journal： Egyptian Journal of Medical Human Genetics

Egyptian Journal of Medical Human Genetics

影响因子：1.1

是否综述期刊：否

是否OA：是

是否预警：不在预警名单内

发行时间：-

ISSN：1110-8630

发刊频率：-

收录数据库：ESCI/Scopus收录/DOAJ开放期刊

出版国家/地区：United Kingdom

出版社：Springer Nature

期刊介绍

年发文量	156
国人发稿量	4
国人发文占比	2.33%
自引率	0.0%
平均录取率	-
平均审稿周期	18 Weeks
版面费	-
偏重研究方向	Medicine-Genetics (clinical)
期刊官网	https://jmhg.springeropen.com
投稿链接	-

质量指标占比

研究类文章占比	OA被引用占比	撤稿占比	出版后修正文章占比
82.69%	100.00%	-	-

预警情况

时间	预警情况
2025年03月发布的2025版	不在预警名单中
2024年02月发布的2024版	不在预警名单中
2023年01月发布的2023版	不在预警名单中
2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q4区

版本	按学科	分区
WOS期刊SCI分区（2021-2022年最新版）
	GENETICS & HEREDITY	Q4

中科院分区

版本	大类学科	小类学科	Top期刊	综述期刊
暂无数据