Journal of Clinical and Aesthetic Dermatology 杂志-刊鹿论文编译

Innumerable Squamous Cell Carcinomas in Vietnam War Veteran Exposed to Chemical Defoliants.

Abstract:

Objective. We present a successful multidisciplinary treatment approach used for a patient with rapidly developing, high-volume, and high-risk squamous cell carcinomas (SCCs), addressing short-term treatment, long-term maintenance, and appropriate preventative strategies in a difficult patient population. Case report. An immunocompetent, 84-year-old, Caucasian man with at least 30 SCCs of the scalp, head, neck, and upper extremities, including a 4-cm SCC on the vertex of the scalp infiltrating to the periosteum, presented to a cutaneous oncology clinic. Initial physical examination revealed nearly confluent, erythematous, hyperkeratotic, crusted papules and plaques on the head, neck, back, arms, and dorsal hands, all of which were clinically obvious SCC. Nonlesional skin displayed widespread epidermal dysplasia. The patient was seen by the clinic s medical oncology and dermatology teams in coordinated dual visits. The invasive scalp lesion was treated by Mohs surgery and radiation, and the large SCC and field cancerization were successfully treated with a combination of topical and intralesional 5-fluorouracil with pulsed oral capecitabine, which resulted in a significant reduction in SCC disease burden. Conclusion. Management of patients with overwhelming numbers of SCCs is extremely challenging. Combination topical and/or intralesional 5-fluorouracil and oral capecitabine may be considered as part of the management approach when mechanical destruction and surgery alone are not feasible. Multidisciplinary care coordinated between the surgeon, dermatologic oncologist, medical oncologist, and radiation oncologist is essential for providing comprehensive treatment and deploying preventative strategies in this population at high risk for metastatic SCC formation.

Author Listing： Jennifer Desimone;Meghan Beatson

Volume： 12 8

Pages： \n 47-50\n

DOI： 10.1016/j.jaad.2019.06.831

Language： English

Journal： The Journal of clinical and aesthetic dermatology

Journal of Clinical and Aesthetic Dermatology

影响因子：0.0

是否综述期刊：否

是否OA：否

是否预警：不在预警名单内

发行时间：-

ISSN：1941-2789

发刊频率：-

收录数据库：Scopus收录

出版国家/地区：-

出版社：Matrix Medical Communications

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自引率	0.0%
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偏重研究方向	Medicine-Dermatology
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时间	预警情况
2025年03月发布的2025版	不在预警名单中
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2023年01月发布的2023版	不在预警名单中
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2020年12月发布的2020版	不在预警名单中

JCR分区 WOS分区等级：Q0区

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WOS期刊SCI分区（2021-2022年最新版）

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版本	大类学科	小类学科	Top期刊	综述期刊
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