咨询客服 咨询客服

Use of air stacking to improve pulmonary function in Indonesian Duchenne muscular dystrophy patients: bridging the standard of care gap in low middle income country setting

Abstract:
BackgroundDuchenne Muscular Dystrophy (DMD) is a fatal X-linked recessive neuromuscular disease, characterized by progressive loss of muscle strength. Respiratory failure is the main cause of morbidity and mortality in DMD patients. Respiratory devices have been reported to increase the effectiveness of cough and pulmonary function, thus prolong the survival rate. However, there is scarcity of studies about DMD patients’ respiratory profiles and usage of respiratory devices in Indonesia.MethodsWe recruited 8 Indonesian DMD patients in Dr. Sardjito Hospital and UGM Academic Hospital, Yogyakarta. Baseline pulmonary function was measured using spirometry. Peak Cough Flow was measured at baseline, with chest compression, after air stacking with manual ventilation bag, and with the combined techniques. Data recorded was presented as mean\u2009±\u2009SD and analysed using ANOVA.ResultsHere we show the respiratory profiles from 8 non-ambulatory DMD patients (mean age: 13.25 ± 3.96\u2009years old) confirmed by genetic testing. None of them had access to respiratory devices. Spirometry measurements showed 7 of 8 patients had severe restrictive pulmonary function with mean FEV1/FVC 22.40 ± 10.30% of predictive values (normal ratio\u2009>\u200970%). In addition, all patients showed poor cough performances measured by peak cough flowmeter (160\u2009±\u200944.58\u2009L/min (normal value >\u2009270\u2009L/min)) that were improved by air stacking using a manual ventilation bag (167.4\u2009±\u200946.72\u2009L/min). Three patients who had nocturnal hypoventilation did not have daytime hypercapnia. Manual ventilation bag or mechanical in−/ex-sufflation was indicated in 75% of patients while nocturnal assisted ventilation was indicated in 50% of patients. Neither daytime assisted ventilation nor tracheostomy was indicated in these patients.ConclusionUse of manual exsufflation in combination with the manual ventilation bag for air stacking to improve cough performance is recommended as the first step of respiratory management in DMD patients. Provision of manual ventilation bag serve as an affordable and effective device for respiratory support in the early stage of respiratory involvement in those non-ambulatory patients with DMD.
Author Listing: Kristy Iskandar;Sunartini;Andika Priamas Nugrahanto;Nissya Ilma;Alvin Santoso Kalim;Guritno Adistyawan;Siswanto;Roni Naning
Volume: 13
Pages: None
DOI: 10.1186/s12919-019-0179-4
Language: English
Journal: BMC Proceedings

BMC Proceedings

影响因子:0.0
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:1753-6561
发刊频率:-
收录数据库:Scopus收录/DOAJ开放期刊
出版国家/地区:United Kingdom
出版社:Springer Nature

期刊介绍

年发文量 -
国人发稿量 -
国人发文占比 -
自引率 0.0%
平均录取率 -
平均审稿周期 10 Weeks
版面费 -
偏重研究方向 Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
期刊官网 http://www.biomedcentral.com/bmcproc/
投稿链接 -

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
0.00% 0.00% - -

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q0区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
暂无数据