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Ultrasound is not associated with the presence of systemic autoimmunity or symptoms in individuals at risk for rheumatoid arthritis

Abstract:
Objective To identify whether musculoskeletal ultrasound (MSUS) abnormalities are associated with specific phases of rheumatoid arthritis (RA) development in individuals at risk of RA. Methods This is a prospective cohort study of individuals at risk of developing RA, namely first-degree relatives of patients with RA (RA-FDRs) without evidence of established rheumatic disease at inclusion. The inflammatory activity on MSUS was assessed according to a validated score (SONAR). Active MSUS was defined as a total B-mode score greater than 8, including at least one joint with significant synovitis (grade 2 or 3) or significant synovial hyperaemia (Doppler score greater than 1). We used logistic regression to analyse associations between MSUS findings and recognised preclinical phases of RA development, adjusting for other demographic and biological characteristics. Results A total of 273 RA-FDRs were analysed, of whom 23 (8%) were anticitrullinated protein autoantibodies-positive, 58 (21%) had unclassified arthritis and 96 (35%) had an active MSUS, which was only associated with unclassified arthritis (OR: 1.8, 95%\u2009CI 1.0 to 3.3). Conclusion In individuals at risk of RA, active MSUS was associated with the presence of unclassified arthritis, but not with any of the earlier described phases of RA development. These findings do not support an indiscriminate use of ultrasound in a screening strategy for preclinical RA.
Author Listing: Laure Brulhart;Deshiré Alpízar-Rodríguez;Michael S Nissen;Pascal Zufferey;Ileana Ciubotariu;Gregory Fleury;Ilias Lazarou;Cem Gabay;Axel Finckh
Volume: 5
Pages: None
DOI: 10.1136/rmdopen-2019-000922
Language: English
Journal: RMD Open

RMD Open

RMD OPEN

影响因子:4.7
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:2056-5933
发刊频率:-
收录数据库:SCIE/Scopus收录/DOAJ开放期刊
出版国家/地区:ENGLAND
出版社:BMJ PUBLISHING GROUP

期刊介绍

年发文量 268
国人发稿量 24
国人发文占比 8.81%
自引率 4.3%
平均录取率 -
平均审稿周期 14 Weeks
版面费 1,950 GBP
偏重研究方向 RHEUMATOLOGY-
期刊官网 https://rmdopen.bmj.com
投稿链接 -

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
97.76% 99.46% 0.00% 2.06%

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q1区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
RHEUMATOLOGY Q1

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
医学
2区
RHEUMATOLOGY
风湿病学
2区
2021年12月
基础版
医学
2区
RHEUMATOLOGY
风湿病学
3区
2021年12月
升级版
医学
2区
RHEUMATOLOGY
风湿病学
2区
2022年12月
最新升级版
医学
2区
RHEUMATOLOGY
风湿病学
2区