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Protein Export into and across the Atypical Diderm Cell Envelope of Mycobacteria.

Abstract:
Mycobacteria, including the infamous pathogen Mycobacterium tuberculosis, are high-GC Gram-positive bacteria with a distinctive cell envelope. Although there is a typical inner membrane, the mycobacterial cell envelope is unusual in having its peptidoglycan layer connected to a polymer of arabinogalactan, which in turn is covalently attached to long-chain mycolic acids that help form a highly impermeable mycobacterial outer membrane. This complex double-membrane, or diderm, cell envelope imparts mycobacteria with unique requirements for protein export into and across the cell envelope for secretion into the extracellular environment. In this article, we review the four protein export pathways known to exist in mycobacteria: two conserved systems that exist in all types of bacteria (the Sec and Tat pathways) and two specialized systems that exist in mycobacteria, corynebacteria, and a subset of low-GC Gram-positive bacteria (the SecA2 and type VII secretion pathways). We describe the progress made over the past 15 years in understanding each of these mycobacterial export pathways, and we highlight the need for research to understand the specific steps of protein export across the mycobacterial outer membrane.
Author Listing: Vincent J C van Winden;Edith N G Houben;Miriam Braunstein
Volume: 7 4
Pages: None
DOI: 10.1128/microbiolspec.GPP3-0043-2018
Language: English
Journal: Microbiology spectrum

Microbiology Spectrum

MICROBIOL SPECTR

影响因子:3.8
是否综述期刊:否
是否OA:否
是否预警:不在预警名单内
发行时间:-
ISSN:2165-0497
发刊频率:-
收录数据库:SCIE/Scopus收录
出版国家/地区:United States
出版社:American Society for Microbiology

期刊介绍

Microbiology Spectrum publishes commissioned review articles on topics in microbiology representing ten content areas: Archaea; Food Microbiology; Bacterial Genetics, Cell Biology, and Physiology; Clinical Microbiology; Environmental Microbiology and Ecology; Eukaryotic Microbes; Genomics, Computational, and Synthetic Microbiology; Immunology; Pathogenesis; and Virology. Reviews are interrelated, with each review linking to other related content. A large board of Microbiology Spectrum editors aids in the development of topics for potential reviews and in the identification of an editor, or editors, who shepherd each collection.

《微生物学光谱》出版关于微生物学主题的委托评论文章,代表十个内容领域:古菌;食品微生物学;细菌遗传学、细胞生物学和生理学;临床微生物学;环境微生物学与生态学;真核微生物;基因组学、计算和合成微生物学;免疫学;发病机制;和病毒学。评论是相互关联的,每个评论都链接到其他相关内容。一个由微生物谱编辑组成的大型委员会协助制定潜在审查的主题,并确定一名或多名编辑,负责指导每个收集。

年发文量 1332
国人发稿量 515
国人发文占比 38.69%
自引率 5.3%
平均录取率 -
平均审稿周期 -
版面费 US$1800
偏重研究方向 Biochemistry, Genetics and Molecular Biology-Genetics
期刊官网 https://www.asmscience.org/microbiologyspectrum
投稿链接 https://login.asm.org/idp/profile/SAML2/Redirect/SSO;jsessionid=node0189peo4diclqufa1grmoabckq8312988.node0?execution=e1s1

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
100.00% 88.87% 0.00% 0.00%

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q2区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
MICROBIOLOGY Q2

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
生物学
1区
MICROBIOLOGY
微生物学
1区
2021年12月
基础版
生物
2区
MICROBIOLOGY
微生物学
2区
2021年12月
升级版
生物学
2区
MICROBIOLOGY
微生物学
2区
2020年12月
旧的升级版
生物学
2区
MICROBIOLOGY
微生物学
2区
2022年12月
最新升级版
生物学
2区
MICROBIOLOGY
微生物学
3区