咨询客服 咨询客服

Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway

Abstract:
Over the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function. Fungal infections cause around 1.5 million deaths annually, superior to malaria and tuberculosis. With respect to high toxicity, narrow spectrum of activity and drug resistance to current antifungals, there is an urgent need to discover novel leads from molecules of natural origin especially those derived from plants and microorganisms for antifungal drug discovery. Among antifungal drugs introduced into the clinic, those affecting ergosterol biosynthesis are still superior to other classes and the vital role of ergosterol in fungal growth and development. This review highlights current knowledge about available antifungal agents and further issues on antifungal drug discovery from compounds of natural origin which affect ergosterol biosynthesis. Special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterol biosynthesis pathway as a novel target for rational drug design.
Author Listing: Fatemehsadat Jamzivar;Masoomeh Shams-Ghahfarokhi;Mansoor Khoramizadeh;Niloufar Yousefi;Mohammadhassan Gholami-Shabani;Mehdi Razzaghi-Abyaneh
Volume: 11
Pages: 448 - 459
DOI: 10.18502/ijm.v11i6.2216
Language: English
Journal: Iranian Journal of Microbiology

Iranian Journal of Microbiology

IRAN J MICROBIOL

影响因子:1.7
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:2008-3289
发刊频率:-
收录数据库:ESCI/Scopus收录/DOAJ开放期刊
出版国家/地区:Iran, Islamic Republic of
出版社:Tehran University of Medical Sciences

期刊介绍

年发文量 100
国人发稿量 -
国人发文占比 0%
自引率 0.0%
平均录取率 -
平均审稿周期 12 Weeks
版面费 -
偏重研究方向 MICROBIOLOGY-
期刊官网 https://ijm.tums.ac.ir
投稿链接 -

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
97.00% 80.26% - -

相关指数

影响因子
影响因子
年发文量
自引率
Cite Score

预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q4区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
MICROBIOLOGY Q4

中科院分区

版本 大类学科 小类学科 Top期刊 综述期刊
暂无数据