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ACE gene polymorphism and its association with serum erythropoietin and hemoglobin \u200ein Iraqi hemodialysis patients

Abstract:
Purpose To evaluate the frequencies of angiotensin-converting enzyme gene \u200epolymorphism in \u200eIraqi hemodialysis patients and to examine the association \u200ebetween this polymorphism and \u200eserum erythropoietin and hemoglobin levels.\u200e Methods In this study, 70 chronic renal failure Iraqi patients on \u200emaintenance \u200ehemodialysis (patient group) and 20 healthy subjects (control \u200egroup) were genotyped for \u200eangiotensin-converting enzyme gene polymorphism. The distribution of genotype and allele \u200efrequencies of this polymorphism in \u200ethese subjects were also evaluated.\u200e Results The distribution of angiotensin-converting enzyme genotypes between \u200egroups was \u200esimilar, and the ID genotype was the most frequent, followed by DD and II \u200egenotypes (\u200e50%\u200e, \u200e37%\u200e, and \u200e13%). The control group \u200ehad a nonsignificant difference in serum \u200eerythropoietin levels among different angiotensin-converting enzyme genotypes, \u200ewhile patients with ID and DD genotypes displayed significant \u200eelevation in \u200eserum erythropoietin with time. No significant differences in hemoglobin \u200elevels \u200ewere observed in patient and control groups. A significant positive correlation \u200ewas \u200eobserved between serum erythropoietin and hemoglobin in the control group \u200ewith different \u200eangiotensin-converting enzyme genotypes, while a nonsignificant \u200enegative correlation was \u200eobserved in the patient group throughout the study. \u200e Conclusions Chronic kidney disease did not significantly alter angiotensin-converting enzyme \u200egenotypes, and angiotensin-converting enzyme gene \u200epolymorphism had a significant effect on \u200eserum erythropoietin levels and a non\u200esignificant effect on hemoglobin levels. \u200e
Author Listing: Mohanad Yasir Al-Radeef;Hayder Adnan Fawzi;Ali Abdulmajid Allawi
Volume: 12
Pages: 107 - 112
DOI: 10.2147/TACG.S198992
Language: English
Journal: The Application of Clinical Genetics

Application of Clinical Genetics

影响因子:2.8
是否综述期刊:否
是否OA:是
是否预警:不在预警名单内
发行时间:-
ISSN:1178-704X
发刊频率:-
收录数据库:ESCI/Scopus收录/DOAJ开放期刊
出版国家/地区:United Kingdom
出版社:Dove Medical Press

期刊介绍

年发文量 22
国人发稿量 -
国人发文占比 0%
自引率 0.0%
平均录取率 -
平均审稿周期 16 Weeks
版面费 -
偏重研究方向 Biochemistry, Genetics and Molecular Biology-Genetics
期刊官网 http://www.dovepress.com/the-application-of-clinical-genetics-journal
投稿链接 -

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
95.45% 96.55% - -

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预警情况

时间 预警情况
2025年03月发布的2025版 不在预警名单中
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q2区

版本 按学科 分区
WOS期刊SCI分区
(2021-2022年最新版)
GENETICS & HEREDITY Q3

中科院分区

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