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Arf GAPs and molecular motors

Abstract:
ABSTRACT Arf GTPase-activating proteins (Arf GAPs) were first identified as regulators of the small GTP-binding proteins ADP-ribosylation factors (Arfs). The Arf GAPs are a large family of proteins in metazoans, outnumbering the Arfs that they regulate. The members of the Arf GAP family have complex domain structures and some have been implicated in particular cellular functions, such as cell migration, or with particular pathologies, such as tumor invasion and metastasis. The specific effects of Arfs sometimes depend on the Arf GAP involved in their regulation. These observations have led to speculation that the Arf GAPs themselves may affect cellular activities in capacities beyond the regulation of Arfs. Recently, 2 Arf GAPs, ASAP1 and AGAP1, have been found to bind directly to and influence the activity of myosins and kinesins, motor proteins associated with filamentous actin and microtubules, respectively. The Arf GAP-motor protein interaction is critical for cellular behaviors involving the actin cytoskeleton and microtubules, such as cell migration and other cell movements. Arfs, then, may function with molecular motors through Arf GAPs to regulate microtubule and actin remodeling.
Author Listing: Ruibai Luo;Christine E Reed;Jeffrey A Sload;Linda Wordeman;Paul A Randazzo;Pei-Wen Chen
Volume: 10
Pages: 196 - 209
DOI: 10.1080/21541248.2017.1308850
Language: English
Journal: Small GTPases

Small GTPases

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ISSN:2154-1248
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收录数据库:Scopus收录
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出版社:Taylor & Francis

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偏重研究方向 Biochemistry, Genetics and Molecular Biology-Biochemistry
期刊官网 https://www.tandfonline.com/toc/ksgt20/current
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2024年02月发布的2024版 不在预警名单中
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2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

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