Drug and Therapeutics Bulletin 投稿方向-刊鹿论文编译

Republished: Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine

Abstract:

In conjunction with BMJ Case Reports, DTB will feature occasional drug-related cases that are likely to be of interest to readers. These will include cases that involve recently marketed drugs for which there is limited knowledge of adverse effects and cases that highlight unusual reactions to drugs that have been marketed for several years.\n\nSexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.\n\nQuetiapine is a commonly used atypical antipsychotic medication.1 It is a dopamine D1 and D2, 5-HT2, alpha1-adrenoceptor and histamine-1 receptor antagonist and is licensed in the UK for the treatment of schizophrenia and bipolar affective disorder and as an adjunctive treatment in depression.2 Retrograde ejaculation (RE), where ejaculate passes into the bladder as oppose to down the urethra, occurs secondary to failure of contraction of the bladder neck. Causes of this include mechanical, for example, surgery, disruption of sympathetic innervation, such as diabetes or pharmacologic (eg, alpha1 antagonism).3 4 RE has been reported to occur with antipsychotic medications including …

Author Listing： Matthew Roughley;Marc Lyall

Volume： 57

Pages： 189 - 191

DOI： 10.1136/dtb.2019.228539rep

Language： English

Journal： Drug and Therapeutics Bulletin

Drug and Therapeutics Bulletin

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ISSN：0012-6543

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收录数据库：Scopus收录

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出版社：BMJ Publishing Group

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偏重研究方向	Medicine-Pharmacology (medical)
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2024年02月发布的2024版	不在预警名单中
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2021年12月发布的2021版	不在预警名单中
2020年12月发布的2020版	不在预警名单中

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WOS期刊SCI分区（2021-2022年最新版）

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